丁松泽

河南省人民医院/郑州大学人民医院

医学博士，消化内科副主任医师，副教授，中心实验室副主任。1992年北京医科大学第一医院内科消化专业博士毕业到河南省人民医院工作，历任消化内科主治、副主任医师。1998年赴美国从事消化系统疾病相关的科研工作，主要进行胃幽门螺杆菌感染的致病、致癌机制、干细胞和表观遗传学等方面的研究。

曾在美国德州大学、弗吉尼亚大学及日本北海道大学等国际著名大学留学、任教。发表多篇系列学术论文，并在国内、外该专业领域取得了相应的学术声誉。现为6家国际专业期刊编委，并以同行专家身份为30余家国际期刊审核论文稿件，2010年以来先后已有300余家国际期刊来函征稿或约稿。

学术研究方向为：幽门螺旋杆菌感染诱发胃癌的分子机制及防治；慢性炎性感染关联癌症的致癌机制及防治。

2013年5月由河南省人民医院/郑州大学人民医院以海外学者引进回国工作。

从事消化系统疾病的临床医疗、科研和教学工作二十余年。

Dr. Song-Ze Ding is an Associate Professor of Gastroenterology, and Associate Director for Center of Translational Medicine atPeople’s Hospital of Zhengzhou University,or Henan Provincial People’s Hospital, in Zhengzhou, Henan, China. He received his MD/Ph.D. from Beijing Medical University in 1992,and firstly served as clinical physician in Gastroenterology and Hepatology, he later pursued postdoctoral work at University of Texas and University of Virginia in Helicobacter pyloriinfection related gastric disease research. Dr. Ding alsoserved as an Associate Professor in Institute for Genetic Medicine at Hokkaido University, in Sapporo, Japan.

Dr. Ding’s research is focused on inflammation, stem cell, epigenetics and epithelial cancer. The primary model is Helicobacter pylori infection related human gastric diseases. He is currently editorial board member for six international journals, also serves as expert reviewer for more than 30reputed international journals, and has more than 30 publications in peer-reviewed international journals.

Research Interests: inflammation and cancer

1．H. pylori infection, oncogenic pathways, stem cell and epithelial cancer

2． Chronic inflammation related cancer and oncogenic transformation

近期发表的论文/ Selected Publications:

1. Chen M, Zheng TH, Han SY, Zhang LD, Bai YQ, Fang XH, Ding SZ, Yang YX. A preliminary study of plasma cyclase-associated protein 2 as a novel biomarker for early stage and alpha-fetoprotein negative hepatocellular carcinoma patients. Clin Res HepatolGastroenterol. 2014 Oct 9. pii: S2210-7401(14)00208-3. doi: 10.1016/j.clinre.2014.08.006. [Epub ahead of print]

2. Zheng T, Chen M, Han S, Zhang L, Bai Y, Fang X, Ding SZ, Yang Y.Plasma minichromosome maintenance complex component 6 is a novel biomarker for hepatocellular carcinoma patients.Hepatol Res. 2014 Jan 23. doi: 10.1111/hepr.12303. [Epub ahead of print].

3. Bai YQ, Yang YG, Jin FL, Cao MB, Yang, YX, Ding SZ,Zhang YR, Zhang BY. Autologous bone marrow mononuclear cell transplantation improves liver function and reduces disease complications in decompensated liver cirrhosis patients. World Journal of Gastroenterology 2014;20:8660-8666.

4. Yang YX, Li XL, Wang L, Han SY, Zhang YR, Pratheeshkumar P, Wang X, Lu J, Yin YQ, Sun LJ, Budhraja A, Hitron AJ, Ding SZ.Anti-apoptotic proteins and catalase-dependent apoptosis resistance in nickel chloride-transformed human lung epithelial cells.Int J Oncol. 2013 Sep;43(3):936-46.(corresponding author).

5. Ding SZ, Yang YX, Li XL, Michelli AR, Han SY, Wang X, Budhraja A, Son YK, Hiltron, AJ. Epithelial-mesenchymal transition during oncogenic transformation induced by Hexavalent Chromium involves reactive oxidative species-dependent mechanism in lung epithelial cells.ToxicolApplPharmacol. 2013; 269: 61–71.(corresponding author).

6. Ding SZand Zheng PY.Helicobacter pylori-induced gastric cancer; advance in gastric stem cell research and the remaining challenges. Gut Pathogens 2012;4:18(corresponding author).

7. Ding SZ,Goldberg JB, Hetakeyama M. Helicobacter pylori infection, oncogenic pathway and epigenetic mechanism in gastric carcinogenesis (review). Future Oncology 2010;6 (5): 849-860(corresponding author).

8. Ding SZ, Fischer W, Kaparakis-Liaskos M, Liechti G, Merrell DS, Grant PA, Ferrero RL, Crowe SE, Haas R, Hatakeyama M, Goldberg JB. Helicobacter pylori-induced histone modification, associated gene expression in gastric epithelial cells, and its implication in pathogenesis. PLoSONE 2010:4 (5); e9875.

9. Ding SZ, Olekanovich, IN, Cover TL, Peek RM Jr., Smith MF Jr., and Goldberg JB. Helicobacter pylori and mitogen-activated protein kinases modulate activator protein-1 subcomponent protein expression and DNA binding activity in gastric epithelial cells.FEMS Immunol Med Microbiol 2008;53 (7):385-394.

10. Ding SZ, Smith MF Jr., and Goldberg JB. Helicobacter pylori and mitogen-activated protein kinases regulate the cell cycle, proliferation and apoptosis in gastric epithelial cells.J Gastroenterol and Hepatol 2008;23 (7 Pt. 2):78-89.

11. Ding SZ, Minohara Y, Fan XJ, Wang, J, Reyes, VE, Patel J, Dirden-Kramer, B, Boldogh I, Ernst, PB, Crowe SE. Helicobacter pylori infection induces oxidative stress and programmed cell death in human gastric epithelial cells. Infect Immun2007;75(8):4030-9.

12. Ding SZ, Torok AM, Smith MF Jr., Goldberg JB. Toll-like receptor 2 mediated gene expression in epithelial cells during Helicobacter pylori infection.Helicobacter 2005;10:193-204.

13. Ding SZ, O'Hara AM, Denning TL, Dirden-Kramer B, Mifflin RC, Reyes VE, Ryan KA, Elliott SN, Izumi T, Boldogh I, Mitra S, Ernst PB, Crowe SE. Helicobacter pylori and H2O2 increase AP endonuclease-1/redox factor-1 expression in human gastric epithelial cells. Gastroenterology. 2004;127(3):845-58.

14. Smith MF Jr, Mitchell A, Li G, Ding S, Fitzmaurice AM, Ryan K, Crowe S, Goldberg JB. Toll-like receptor (TLR) 2 and TLR5, but not TLR4, are required for Helicobacter pylori-induced NF-kappa B activation and chemokine expression by epithelial cells. J Biol Chem. 2003;278(35):32552-60.

15. Ding SZ, Crowe SE. Helicobacter pylori and the epithelial barrier: Role of oxidative injury. In: Hunt, R.H., Tytgat, G.N.J., ed. Helicobacter pylori: Basic mechanisms to clinical cure 2000. Lancaster, UK: Kluwer Academic Publishers, 2000