:十二指肠上皮内淋巴细胞数量增多（IELs）可以表征乳糜泻（CD），但是也可以用来描述非乳糜泻症状。IELs增加和幽门螺杆菌感染之间是否具有相关性一直存在争议，在儿童中十二指肠上皮内淋巴细胞增多很常见。
:Increased numbers of duodenal intraepithelial lymphocytes (IELs) characterise coeliac disease (CD) but have also been described in noncoeliacs. Controversy exists regarding an association between increased IELs and infection with Helicobacter pylori, which is commonly found in children.
:为了评估幽门螺杆菌感染和十二指肠IELs之间的关系，采用了大型儿童队列研究，这些儿童包括患和不患乳糜泻疾病。
:To assess the relationship between H. pylori infection and duodenal IELs in a large cohort of children, with and without CD.
:我们对在2006年1月到2013年2月在以色列的Schneider儿童医学中心（以色列最大的医疗保健组织转介中心），由于反复发作腹痛（RAP）或者疑似乳糜泻接受胃镜检查儿童的胃和十二指肠活检进行回顾。每一个标本根据十二指肠IEL数量和胃窦部呈现的幽门螺旋杆菌活检进行确认。
:We reviewed gastric and duodenal biopsies of children who underwent esophagogastroduodenoscopy between January 2006 and February 2013 because of either recurrent abdominal pain (RAP) or suspected CD at Schneider Children's Medical Center of Israel, a referral centre for Israel's largest Health Maintenance Organization. The duodenal IEL count and H. pylori presence in antral biopsies were determined for each specimen.
:患有PAP（n=693）或者CD（n=306）的儿童均被纳入研究。在RAP儿童中，有33.8%的孩子出现幽门螺杆菌感染。幽门螺杆菌阳性RAP组中平均IEL数量是17.8（±8.8）/100肠细胞单位，vs 幽门螺杆菌阴性RAP组15.8（±8.3）。有15.7%的幽门螺杆菌阴性，非乳糜泻儿童被发现IEL数量增加（≥25 IELs/100肠细胞单位）。乳糜泻儿童中，根据幽门螺杆菌状态IEL数量没有明显差异：幽门螺杆菌阳性患者73.1(±26.1) vs幽门螺杆菌阴性患者72.6 (±26.5)。
:Children with RAP (n = 693) or CD (n = 306) were included. Among children with RAP, H. pylori was present in 33.8%. The mean IEL count in the H. pylori positive RAP group was 17.8(±8.8)/100 enterocytes, vs. 15.8(±8.3) in the H. pylori negative patients (P = 0.004). Increased IEL counts (≥25 IELs/100 enterocytes) were found in 15.7% of H. pylori negative, noncoeliac children. Among children with CD, there was no significant difference in IEL counts according to H. pylori status: 73.1(±26.1) vs. 72.6 (±26.5) in H. pylori positive and negative patients respectively.
:我们的研究结果表明，轻度升高的十二指肠上皮内淋巴细胞数量在儿科人群很常见。幽门螺杆菌感染对反复发作腹痛儿童或者乳糜泻儿童的上皮内淋巴细胞数量没有重大影响。
:Our study suggests that slightly elevated duodenal intraepithelial lymphocyte counts are common in the paediatric population. Helicobacter pylori infection has no major influence on the intraepithelial lymphocyte counts in children with recurrent abdominal pain or children with coeliac disease.